PURPOSE: The aim is to investigate the effect of alternate occlusion on control of intermittent exotropia in children 3 to 8 years old. METHODS: The ability of 28 children to control of the deviation at far and near was evaluated based on 3-point and 6-point control scales. Stereopsis and fusion were assessed using the Titmus and Worth 4-dot tests, respectively. Two-hour alternate daily occlusion was prescribed for children with no dominancy. For children with a dominant eye, 2-h occlusion of the dominant eye for 5 days and the non-dominant eye for 2 days. All measurements were repeated at 3, 6, and 9 months after the treatment. RESULTS: For all children with a mean age of 4.7 ± 1.56 years, deviation control at far improved significantly after 3, 6, and 9 months of treatment using both control scales when compared with baseline ( = 0.005 after 3 months and  = 0.008 after 6 and 9 months for the 3-point scale, and  < 0.001 after 3 and 6 months and  = 0.010 after 9 months for the 6-point scale). Control at near showed a significant improvement after 3, 6, and 9 months of treatment based on the 6-point scale ( = 0.007 for 3 months,  = 0.004 for 6 months, and  = 0.014 for 9 months). Near stereopsis improved significantly after 9 months of treatment ( = 0.043). CONCLUSION: Alternate occlusion is significantly effective on control of intermittent exotropia. As a result, it can be used as a useful method to postpone or even eliminate the need for surgery in intermittent exotropia.