Brown J C
Baillieres Clin Endocrinol Metab. 1988 May;2(2):359-73. doi: 10.1016/s0950-351x(88)80037-5.
A physiological role for GIP as an insulinotropic hormone involved in the enteroinsular axis has been established and ingestion of glucose, fatty acids and certain amino acids will produce an increase in circulating IR-GIP levels. The insulinotropic action of GIP is glucose concentration dependent in normal animals. A role for GIP in NIDDM is equivocal although several studies have demonstrated elevated serum levels. Animal models have indicated a disturbance of GIP receptor function associated with hyperinsulinaemia, i.e. lowering of the minimum glucose concentration at which GIP is insulinotropic.
GIP作为一种参与肠胰岛轴的促胰岛素激素的生理作用已得到确立，摄入葡萄糖、脂肪酸和某些氨基酸会使循环中的免疫反应性GIP（IR-GIP）水平升高。在正常动物中，GIP的促胰岛素作用取决于葡萄糖浓度。尽管多项研究表明血清水平升高，但GIP在非胰岛素依赖型糖尿病（NIDDM）中的作用仍不明确。动物模型显示，GIP受体功能紊乱与高胰岛素血症有关，即降低GIP发挥促胰岛素作用的最低葡萄糖浓度。
