HIV/AIDS 患者的多种药物治疗和药物相关问题：单中心经验。
Polypharmacy and drug-related problems among people living with HIV/AIDS: a single-center experience.
出版信息
Turk J Med Sci. 2019 Feb 11;49(1):222-229. doi: 10.3906/sag-1807-295.
BACKGROUND/AIM: The HIV-infected population is aging, and the concomitant comorbidities increase the likelihood of polypharmacy. There is a scarcity of data for determining drug-related problems in people living with HIV/AIDS (PLWHA).
MATERIALS AND METHODS
This cross-sectional study was carried out between 1 September 2015 and 1 July 2016. All patients underwent a face-to-face interview with a clinical pharmacist. PCNE Classification V 7.0 was used classify incident drug-related problems (DRPs).
RESULTS
The mean age of the patients was 40.4 ± 13.06 years. The rate of polypharmacy was 66.1% in patients with comorbidities and 12.3% in those without comorbidities (P < 0.001). DRPs were more prominent in older patients (46 vs. 37 years, P < 0.001), those with longer durations of antiretroviral therapy (ART) (45 vs. 27 months, P = 0.014), and those with lower education levels (P = 0.013). Receiving >3 ART drugs was associated with more DRPs in the logistic regression model (odds ratio: 8.299, 95% confidence interval: 1.924–35.803). Fifty-eight interventions were performed in 45 (24.9%) patients. Clinical pharmacist interventions were performed in 18.9% of patients without polypharmacy and in 38.9% of patients with polypharmacy (P < 0.001).
CONCLUSION
DRPs and polypharmacy are common among elderly PLWHA. More interventions are warranted to boost the quality of life in aging PLWHA.
背景/目的：感染艾滋病毒的人群正在老龄化，同时伴随的合并症增加了多种药物治疗的可能性。目前，关于艾滋病毒/艾滋病感染者（PLWHA）药物相关问题的数据很少。
材料和方法
本横断面研究于 2015 年 9 月 1 日至 2016 年 7 月 1 日进行。所有患者均接受临床药师的面对面访谈。使用 PCNE 分类 V 7.0 对药物相关问题（DRP）进行分类。
结果
患者的平均年龄为 40.4 ± 13.06 岁。有合并症的患者中，同时使用多种药物的比例为 66.1%，无合并症的患者为 12.3%（P < 0.001）。年龄较大的患者（46 岁比 37 岁，P < 0.001）、接受抗逆转录病毒治疗（ART）时间较长的患者（45 个月比 27 个月，P = 0.014）以及受教育程度较低的患者（P = 0.013）中 DRP 更为突出。在逻辑回归模型中，接受>3 种 ART 药物与更多的 DRP 相关（比值比：8.299，95%置信区间：1.924-35.803）。在 45 名患者（24.9%）中进行了 58 次干预。在无多种药物治疗的患者中，临床药师干预率为 18.9%，在有多种药物治疗的患者中为 38.9%（P < 0.001）。
结论
老年 PLWHA 中药物相关问题和多种药物治疗较为常见。需要更多的干预措施来提高老年 PLWHA 的生活质量。
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