遗传性平滑肌瘤病和肾细胞癌综合征相关肾细胞癌表现为高 FDG 摄取。

Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome-Associated Renal Cell Carcinoma Showing High FDG Uptake.

机构信息

Department of Nuclear Medicine, Changhai Hospital, Second Military Medical University.

Department of Pathology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

出版信息

Clin Nucl Med. 2019 May;44(5):420-423. doi: 10.1097/RLU.0000000000002495.

DOI:10.1097/RLU.0000000000002495

PMID:30762823

Abstract

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome is a rare autosomal-dominant disease, characterized by the development of cutaneous and uterine leiomyomas and renal cell carcinoma (RCC). Approximately 20% to 30% of patients with HLRCC syndrome develop RCC resembling sporadic type 2 papillary RCC, which is aggressive and associated with a poor prognosis. Information on the clinical usefulness of FDG PET/CT in HLRCC syndrome-associated RCC is limited. We present a case of HLRCC syndrome-associated RCC showing high FDG uptake in both the primary RCC and retroperitoneal lymph node metastases. In addition, the patient had 2 hypermetabolic uterine leiomyomas.

摘要

遗传性平滑肌瘤病和肾细胞癌（HLRCC）综合征是一种罕见的常染色体显性疾病，其特征为皮肤和子宫平滑肌瘤以及肾细胞癌（RCC）的发展。大约 20%至 30%的 HLRCC 综合征患者发生类似于散发性 2 型乳头状 RCC 的 RCC，这种 RCC 具有侵袭性，预后不良。关于 FDG PET/CT 在 HLRCC 综合征相关 RCC 中的临床应用的信息有限。我们报告了一例 HLRCC 综合征相关的 RCC 病例，该病例在原发性 RCC 和腹膜后淋巴结转移中均显示出高 FDG 摄取。此外，该患者还有 2 个高代谢性的子宫平滑肌瘤。