金黄色葡萄球菌 TarP：是一堵墙的砖头还是罗塞塔石碑？
Staphylococcus aureus TarP: A Brick in the Wall or Rosetta Stone?
机构信息
Department of Microbiology, The University of Chicago, 920 East 58(th) Street, Chicago, IL 60637, USA.
出版信息
Cell Host Microbe. 2019 Feb 13;25(2):182-183. doi: 10.1016/j.chom.2019.01.013.
Abstract
Staphylococcus aureus infection elicits antibodies against wall teichoic acid (WTA). Several glycosyltransferases modify WTA to generate anomeric heterogeneity. In recent work, Gerlach et al. (2018) show that modification by prophage-encoded TarP diminishes WTA immunogenicity, allowing staphylococci to evade host adaptive immune responses, and propose to exploit these insights for vaccines.
摘要
金黄色葡萄球菌感染会引发针对壁磷壁酸（WTA）的抗体。几种糖基转移酶修饰 WTA 以产生端基异构性。在最近的研究中，Gerlach 等人（2018 年）表明，噬菌体编码的 TarP 的修饰会降低 WTA 的免疫原性，使葡萄球菌能够逃避宿主适应性免疫反应，并提议利用这些见解开发疫苗。
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