Department of Microbiology, The University of Chicago, 920 East 58(th) Street, Chicago, IL 60637, USA.
Cell Host Microbe. 2019 Feb 13;25(2):182-183. doi: 10.1016/j.chom.2019.01.013.
Staphylococcus aureus infection elicits antibodies against wall teichoic acid (WTA). Several glycosyltransferases modify WTA to generate anomeric heterogeneity. In recent work, Gerlach et al. (2018) show that modification by prophage-encoded TarP diminishes WTA immunogenicity, allowing staphylococci to evade host adaptive immune responses, and propose to exploit these insights for vaccines.
金黄色葡萄球菌感染会引发针对壁磷壁酸（WTA）的抗体。几种糖基转移酶修饰 WTA 以产生端基异构性。在最近的研究中，Gerlach 等人（2018 年）表明，噬菌体编码的 TarP 的修饰会降低 WTA 的免疫原性，使葡萄球菌能够逃避宿主适应性免疫反应，并提议利用这些见解开发疫苗。
