中年认知储备与晚年淀粉样蛋白-β沉积无关。
Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life.
机构信息
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Kaiser Permanente Center for Health Research, Portland, OR, USA.
出版信息
J Alzheimers Dis. 2019;68(2):517-521. doi: 10.3233/JAD-180785.
Abstract
We examined associations between cognitive reserve and late-life amyloid-β deposition using florbetapir positron emission tomography (PET). We used data from the Atherosclerosis Risk in Communities (ARIC) and ARIC-PET Study. 330 dementia-free participants underwent PET scans. Mean global cortical standardized uptake value ratio (SUVR) >1.2 was defined as elevated. Midlife cognition was significantly associated with late-life cognition, but not with late-life elevated SUVR; education was not associated with late-life SUVR, but was strongly associated with late-life cognition. Cognitive reserve may reduce dementia risk by mitigating the impact of Alzheimer's disease pathology on the clinical expression of dementia, rather than by altering its pathogenesis.
摘要
我们使用氟代脱氧葡萄糖正电子发射断层扫描（PET）来研究认知储备与老年期淀粉样蛋白-β沉积之间的关联。我们使用了动脉粥样硬化风险社区（ARIC）和 ARIC-PET 研究的数据。330 名无痴呆症的参与者接受了 PET 扫描。平均全脑皮质标准化摄取值比值（SUVR）>1.2 定义为升高。中年认知与老年认知显著相关，但与老年期 SUVR 升高不相关；教育与老年期 SUVR 不相关，但与老年期认知显著相关。认知储备可能通过减轻阿尔茨海默病病理对痴呆临床表现的影响来降低痴呆风险，而不是通过改变其发病机制。
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