School of Pharmacy, University of Eastern Finland, Kuopio, Finland
School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
J Epidemiol Community Health. 2019 May;73(5):451-454. doi: 10.1136/jech-2018-211960. Epub 2019 Feb 19.
Injuries caused by falling are a major health concern among older population. For older people, falls are the leading cause of head injuries; especially, persons with cognitive disorders have an increased risk of falling.
To compare the incidence of head injury and traumatic brain injury (TBI) among persons with Alzheimer's disease (AD) with persons without AD.
This register-based study was conducted on a nationwide cohort, which includes all community-dwelling persons diagnosed with AD in Finland in 2005-2011. Persons with previous head injuries were excluded, leaving 67 172 persons with AD. For each person with AD, a matching person without AD and previous head injury were identified with respect to age, sex and university hospital district. The Cox proportional hazard model and competing risk analyses were used to estimate HR for head injury and TBI.
Persons with AD had 1.34-fold (95% CI 1.29 to 1.40) risk of head injuries and 1.49-fold (95% CI 1.40 to 1.59) risk of TBIs after accounting for competing risks of death and full adjustment by socioeconomic status, drug use and comorbidities.
Persons with AD are more likely to have a head injury or TBI incident than persons without AD.
跌倒造成的伤害是老年人的一个主要健康问题。对于老年人来说，跌倒是头部受伤的主要原因；特别是有认知障碍的人，跌倒的风险更高。
比较阿尔茨海默病（AD）患者与非 AD 患者的头部损伤和创伤性脑损伤（TBI）的发生率。
这项基于登记的研究是在一个全国性队列中进行的，该队列包括 2005 年至 2011 年间在芬兰被诊断为 AD 的所有居住在社区的人。排除了有先前头部损伤的人，留下了 67172 名 AD 患者。对于每一位 AD 患者，根据年龄、性别和大学医院区域，确定了一位与之相匹配的非 AD 患者和无先前头部损伤的患者。使用 Cox 比例风险模型和竞争风险分析来估计头部损伤和 TBI 的 HR。
AD 患者在考虑到死亡的竞争风险和社会经济地位、药物使用和合并症的完全调整后，头部损伤的风险增加 1.34 倍（95%CI 1.29 至 1.40），TBI 的风险增加 1.49 倍（95%CI 1.40 至 1.59）。
AD 患者发生头部损伤或 TBI 的风险高于非 AD 患者。
