Emerg Infect Dis. 2019 Mar;25(3):457-464. doi: 10.3201/eid2503.180572.
We investigated the epidemiology of extrapulmonary tuberculosis (TB) among patients admitted to Beijing Chest Hospital, Beijing, China, during January 2008-December 2017. Of 19,279 hospitalized TB patients, 33.4% (6,433) had extrapulmonary TB and 66.6% (12,846) had pulmonary TB. The most frequent forms of extrapulmonary TB observed were skeletal TB (41.1%) and pleural TB (26.0%). Younger, female patients from rural areas were more likely to have extrapulmonary TB. However, patients with diabetes mellitus were less likely to have extrapulmonary TB compared with patients without diabetes. A higher proportion of multidrug-resistant (MDR) TB was observed among patients with extrapulmonary TB than among patients with pulmonary TB. We observed a large increase in MDR TB, from 17.3% to 35.7%, for pleural TB cases. The increasing rate of drug resistance among extrapulmonary TB cases highlights the need for drug susceptibility testing and the formulation of more effective regimens for extrapulmonary TB treatment.
我们调查了 2008 年 1 月至 2017 年 12 月期间在北京胸科医院住院的结核病患者中肺外结核病(TB)的流行病学情况。在 19279 例住院结核病患者中,33.4%(6433 例)患有肺外结核病,66.6%(12846 例)患有肺结核。观察到最常见的肺外结核病形式是骨骼结核病(41.1%)和胸膜结核病(26.0%)。来自农村地区的年轻、女性患者更有可能患有肺外结核病。然而,与没有糖尿病的患者相比,患有糖尿病的患者患肺外结核病的可能性较小。与肺结核患者相比,肺外结核病患者中观察到更多的耐多药(MDR)结核病。我们观察到胸膜结核病病例中 MDR-TB 的比例从 17.3%大幅上升至 35.7%。肺外结核病病例中耐药率的上升突出表明需要进行药敏试验,并制定更有效的治疗方案。