a Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital , Kaohsiung Medical University , Kaohsiung , Taiwan.
b Department of Internal Medicine, Kaohsiung Medical University Hospital , Kaohsiung Medical University , Kaohsiung , Taiwan.
Expert Rev Gastroenterol Hepatol. 2019 Jan;13(1):17-24. doi: 10.1080/17474124.2019.1542299. Epub 2018 Nov 13.
Gastric cancer is one of the top causes of cancer-related death worldwide. How to eliminate gastric cancer is an urgent public-health issue. Areas covered: In this review, we present up-to-date results of studies on gastric cancer prevention through the eradication of Helicobacter pylori and discuss strategies and obstacles for the implementation of population-wide screening and treatment of this pathogen to prevent gastric cancer. Expert commentary: Gastric cancer is an inflammation-associated cancer with multistep carcinogenesis. The process consists of H. pylori infection, ongoing inflammation, development of metaplastic epithelia and genetic instability eventuating in gastric cancer. H. pylori infection is critical for development of the disease and studies have consistently shown that H. pylori eradication results in a reduction in (a) gastric mucosal inflammation, (b) progression of histologic damage, (c) risk of peptic ulcers and ulcer recurrence, and (d) risk of gastric cancer. Compared with a large number of clinical trials evaluating chemopreventive approaches, studies of population-wide screening, and eradication of H. pylori have only recently begun and only in high-risk populations. To eliminate gastric cancer requires information on how to implement an effective program for screening and treatment of H. pylori taking into consideration the other health priorities in any specific population.
胃癌是全球癌症相关死亡的主要原因之一。如何消除胃癌是一个紧迫的公共卫生问题。
在这篇综述中，我们介绍了通过根除幽门螺杆菌预防胃癌的最新研究结果，并讨论了实施针对这种病原体的人群筛查和治疗策略及障碍，以预防胃癌。
胃癌是一种与炎症相关的癌症，具有多步骤的癌变过程。该过程包括幽门螺杆菌感染、持续的炎症、上皮化生的发展以及导致胃癌的遗传不稳定性。幽门螺杆菌感染对疾病的发展至关重要，研究一致表明，根除幽门螺杆菌可降低(a)胃黏膜炎症、(b)组织学损伤进展、(c)消化性溃疡和溃疡复发风险，以及(d)胃癌风险。与大量评估化学预防方法的临床试验相比，人群筛查和幽门螺杆菌根除的研究最近才开始，并且仅在高危人群中进行。要消除胃癌，需要考虑到任何特定人群中的其他健康优先事项，了解如何实施针对幽门螺杆菌的有效筛查和治疗计划。
