Tournier M, Montastruc F
Centre hospitalier Charles-Perrens, 33000 Bordeaux, France; University of Bordeaux, Inserm, Bordeaux population health research center, pharmacoepidemiology research team, UMR 1219, 33000 Bordeaux, France; DRUGS-SAFE National Platform of Pharmacoepidemiology, 33000 Bordeaux, France.
Service de pharmacologie médicale et clinique, centre de pharmacovigilance, pharmacoépidémiologie et d'informations sur le médicament, centre hospitalier universitaire, faculté de médecine, 31000 Toulouse, France; Unité clinique de pharmacologie psychiatrique, faculté de médecine, centre hospitalier universitaire, 31000 Toulouse, France; UMR 1027 pharmacoepidemiology, assessment of drug utilization and drug safety, Inserm, University Paul-Sabatier-Toulouse III joint research unit, 31000 Toulouse, France; CIC 1436, centre hospitalier universitaire, 31000 Toulouse, France.
Therapie. 2019 Apr;74(2):239-244. doi: 10.1016/j.therap.2019.01.007. Epub 2019 Feb 2.
In psychiatry, drug evaluation using pharmacoepidemiological methods has been of growing interest in recent decades. Studies based on observational databases are particularly useful for psychotropic drugs due to their important prevalence in populations, and their use over long period. The authors discussed the specific interest of pharmacoepidemiological studies in the field of psychiatry through two examples: first, the use of antidepressants, and, second, the risks associated with antipsychotics.
在精神病学领域，近几十年来，运用药物流行病学方法进行药物评估越来越受到关注。基于观察性数据库的研究对于精神药物尤为有用，因为它们在人群中具有较高的患病率，且使用时间较长。作者通过两个例子讨论了药物流行病学研究在精神病学领域的特殊意义：其一，抗抑郁药的使用；其二，抗精神病药物相关的风险。
