Department of Biotechnology, Motilal Nehru National Institute of Technology Prayagraj, Uttar Pradesh, 211004, India.
Nanomedicine (Lond). 2019 Mar;14(6):766-796. doi: 10.2217/nnm-2018-0170. Epub 2019 Feb 22.
Gold nanostructures (GNSts) have emerged as substitute for conventional contrast agents in imaging techniques and therapeutic probes due to their tunable surface plasmon resonance and optical properties in near-infrared region. Thus GNSts provide platform for the amalgamation of diagnosis and treatment (theranostics) into a single molecule for a more precise treatment. Hence, the article talks about the application of GNSts in imaging techniques and provide a holistic view on differently shaped GNSts in cancer theranostics. However, with promises GNSts also face various hurdles for their use as theranostic probe which are primarily associated with toxicity. Finally, the article attempts to discuss the challenges faced by GNSts and the way ahead that need to be traversed to place them in nanomedicine.
金纳米结构(GNSts)由于其在近红外区域可调谐的表面等离子体共振和光学性质,已经成为成像技术和治疗探针中传统对比剂的替代品。因此,GNSts 为将诊断和治疗(治疗学)融合到单个分子中以进行更精确的治疗提供了平台。因此,本文讨论了 GNSts 在成像技术中的应用,并对不同形状的 GNSts 在癌症治疗学中的应用进行了全面的讨论。然而,GNSts 在作为治疗探针的应用方面也面临着各种障碍,这些障碍主要与毒性有关。最后,本文试图讨论 GNSts 面临的挑战以及需要克服的前进方向,以便将它们应用于纳米医学。