通过聚合物纤维的静电纺丝模拟致密纤维组织的取向和极化特性。
Simulating orientation and polarization characteristics of dense fibrous tissue by electrostatic spinning of polymeric fibers.
作者信息
Shen Shuwei, Wang Haili, Qu Yingjie, Huang Kuiming, Liu Guangli, Chen Zexin, Ma Canzhen, Shao Pengfei, Hong Jin, Lemaillet Paul, Dong Erbao, Xu Ronald X
机构信息
Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei 230026, China.
Key Laboratory of Environmental Optics and Technology, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Hefei 230031, China.
出版信息
Biomed Opt Express. 2019 Jan 15;10(2):571-583. doi: 10.1364/BOE.10.000571. eCollection 2019 Feb 1.
Phantoms simulating polarization characteristics of soft tissue play an important role in the development, calibration, and validation of diagnostic polarized imaging devices and of therapeutic strategy, in both laboratory and clinical settings. We propose to fabricate optical phantoms that simulate polarization characteristics of dense fibrous tissues by bonding electrospun polylactic acid (PLA) fibers between polydimethylsiloxane (PDMS) substrate with a groove. Increasing the rotational speed of an electrospinning collector helps improve the orientation of the electrospun fibers. The phantoms simulate the polarization characteristics of dense fibrous tissue of collagenous fibroma and healthy skin with high fidelity. Our experiments demonstrate the technical potential of using such phantoms for validation and calibration of polarimetric medical devices.
模拟软组织偏振特性的体模在诊断偏振成像设备的开发、校准和验证以及治疗策略中，在实验室和临床环境中都发挥着重要作用。我们建议通过将电纺聚乳酸（PLA）纤维粘结在带有凹槽的聚二甲基硅氧烷（PDMS）基板之间来制造模拟致密纤维组织偏振特性的光学体模。提高静电纺丝收集器的转速有助于改善电纺纤维的取向。这些体模能高度逼真地模拟胶原纤维瘤和健康皮肤的致密纤维组织的偏振特性。我们的实验证明了使用这种体模对偏振医疗设备进行验证和校准的技术潜力。
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