Akhter Khaleda, Enamur Rashid Mohammed
Department of Periodontology and Oral Pathology, (Division of Oral Medicine), Pioneer Dental College and Hospital, Dhaka University, Dhaka, Bangladesh. Email:
Asian Pac J Cancer Prev. 2019 Feb 26;20(2):503-508. doi: 10.31557/APJCP.2019.20.2.503.
Background: The study aims to analyze Thymidylate Synthase (TS) and Dihydropyrimidine Dehydrogenase (DPD) Expressions on 5-Fluorouracil in Oral Squamous Cell Carcinoma (OSCC). Methods: 50 oral squamous cell carcinoma samples were taken from non-treated cancer patients at Hiroshima University Dental Hospital. The patients were investigated for TS, that included 36 males and 14 females. Additionally, 31 patients were evaluated for DPD that included 22 males and 9 females. Results: The samples had also undergone clinical and pathological evaluation, immunohistochemical staining, evaluation of immune-staining, enzymatic expression, and statistical analyses. Mean age of the population was 62.1 years. Conclusion: Over-expression of TS contributes significantly to the resistance of 5-FU treatment; while inhibition of intra-tumoral DPD increases the sensitivity level. TS levels are not only predictive of 5-FU response, but also prognostic in clinical value of non-treated cancer patients.
本研究旨在分析口腔鳞状细胞癌（OSCC）中胸苷酸合成酶（TS）和二氢嘧啶脱氢酶（DPD）对5-氟尿嘧啶的表达情况。方法：从广岛大学牙科医院未接受治疗的癌症患者中采集50份口腔鳞状细胞癌样本。对患者进行TS检测，其中包括36名男性和14名女性。此外，对31名患者进行DPD评估，其中包括22名男性和9名女性。结果：样本还进行了临床和病理评估、免疫组织化学染色、免疫染色评估、酶表达及统计分析。人群的平均年龄为62.1岁。结论：TS的过度表达显著导致对5-FU治疗的耐药性；而肿瘤内DPD的抑制可提高敏感性水平。TS水平不仅可预测5-FU反应，在未治疗癌症患者的临床价值中也具有预后意义。
Zotero 插件