Resic Nerma, Durak-Nalbantic Azra, Dzubur Alen, Begic Alden, Begic Edin
Intensive Care Unit, Clinic for Heart, Blood Vessel and Rheumatic Diseases, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Department of Cardiology, Clinic for Heart, Blood Vessel and Rheumatic Diseases, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Med Arch. 2018 Dec;72(6):406-409. doi: 10.5455/medarh.2018.72.406-409.
In patients with acute myocardial infarction (AMI) early risk assessment of development of complications is of great importance. It is proven that aldosterone level has a major role in progression of cardiovascular pathology.
Determination of influence of aldosterone plasma level in the progression of heart disease in patients without signs of heart failure after AMI.
Research included 207 patients, hospitalized in the acute phase of myocardial infarction, and who were divided into two groups: 127 patients with no clinical signs of heart failure and 60 patients with heart failure.
The serum aldosterone concentration was 73.4% higher in the group of decompensated patients, 128 pg/mL (75.4-236 pg/mL) in decompensated and 73.7 pg/mL (42.7 -115.25 pg/mL) in compensated. In the group of compensated patients, changes in aldosterone levels showed a statistically significant effect on the incidence of post-infarction angina (p=0.0001) as well as reinfarction (p=0.009). There is a connection between changes in aldosterone plasma level and positive stress test (p=0.012).
In patients with AMI, elevated serum aldosterone level can be prognostic factor of the progression of coronary heart disease, development of heart failure, as well of development of post-infarction angina, myocardial reinfarction and pathological finding on the stress test.
在急性心肌梗死（AMI）患者中，早期对并发症发生风险进行评估至关重要。已证实醛固酮水平在心血管疾病进展中起主要作用。
确定急性心肌梗死后无心力衰竭体征患者血浆醛固酮水平对心脏病进展的影响。
研究纳入207例在心肌梗死急性期住院的患者，分为两组：127例无心力衰竭临床体征的患者和60例有心力衰竭的患者。
失代偿组患者血清醛固酮浓度高73.4%，失代偿组为128 pg/mL（75.4 - 236 pg/mL），代偿组为73.7 pg/mL（42.7 - 115.25 pg/mL）。在代偿组患者中，醛固酮水平变化对梗死后心绞痛发生率（p = 0.0001）以及再梗死发生率（p = 0.009）有统计学显著影响。醛固酮血浆水平变化与应激试验阳性之间存在关联（p = 0.012）。
在急性心肌梗死患者中，血清醛固酮水平升高可能是冠心病进展、心力衰竭发生、梗死后心绞痛发生、心肌再梗死以及应激试验病理结果的预后因素。
