Lin J Y, Gong Z H, Zheng J, Hu G X
Graduate Institute, Guangzhou Medical University, Guangzhou 511436, China; Infection Department, Peking University Shenzhen Hospital, Shenzhen 518036, China; Gastroenterology Department, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.
Infection Department, Peking University Shenzhen Hospital, Shenzhen 518036, China.
Zhonghua Gan Zang Bing Za Zhi. 2019 Feb 20;27(2):149-152. doi: 10.3760/cma.j.issn.1007-3418.2019.02.016.
Hepatic fibrosis is a wound healing and scar repair reaction after liver injury, and is a common pathway for various chronic liver diseases. Activation and proliferation of hepatic stellate cells are the key links in the occurrence and development of hepatic fibrosis. Recent studies have shown that long non-coding RNAs are involved in regulating the activation, proliferation and apoptosis of hepatic stellate cells. Thus, probing its mechanism of action will provide a new strategy for the diagnosis, treatment and prognosis in liver fibrosis.
肝纤维化是肝脏损伤后的一种伤口愈合和瘢痕修复反应，是各种慢性肝病的共同途径。肝星状细胞的激活和增殖是肝纤维化发生发展的关键环节。近年来的研究表明，长链非编码RNA参与调控肝星状细胞的激活、增殖和凋亡。因此，探究其作用机制将为肝纤维化的诊断、治疗及预后提供新的策略。
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