Swerdlow N R, Geyer M A, Vale W W, Koob G F
Psychopharmacology (Berl). 1986;88(2):147-52. doi: 10.1007/BF00652231.
A series of experiments was performed to investigate the effects of corticotropin-releasing factor (CRF) on the amplitude of the acoustic startle response (ASR) in rats. Intracerebroventricular (ICV) administration of 1 microgram rat CRF significantly potentiated acoustic startle amplitude; these effects were reversed in a dose-dependent manner by pretreatment with the benzodiazepine chlordiazepoxide (CDP). Doses of CDP that antagonized CRF-potentiated ASR did not lower startle baseline or antagonize amphetamine- or strychnine-potentiated ASR. These results suggest that CRF has "anxiogenic" properties and may serve as a neuroendocrine modulator of stress-enhanced behaviors.
进行了一系列实验以研究促肾上腺皮质激素释放因子（CRF）对大鼠听觉惊吓反应（ASR）幅度的影响。脑室内（ICV）注射1微克大鼠CRF可显著增强听觉惊吓幅度；用苯二氮䓬类氯氮䓬（CDP）预处理可呈剂量依赖性逆转这些效应。拮抗CRF增强的ASR的CDP剂量不会降低惊吓基线，也不会拮抗苯丙胺或士的宁增强的ASR。这些结果表明，CRF具有“致焦虑”特性，可能作为应激增强行为的神经内分泌调节剂。
Zotero 插件