乙炔雌二醇和左炔诺孕酮在回肠造口术患者中的生物利用度。

The bioavailability of ethinyloestradiol and levonorgestrel in patients with an ileostomy.

作者信息

Grimmer S F, Back D J, Orme M L, Cowie A, Gilmore I, Tjia J

出版信息

Contraception. 1986 Jan;33(1):51-9. doi: 10.1016/0010-7824(86)90032-6.

Abstract

The bioavailability of ethinyloestradiol and levonorgestrel has been studied in 5 young women with an ileostomy following surgery for ulcerative colitis and compared to that in 5 control subjects. Single i.v. and oral doses of both drugs were administered and the bioavailability calculated from the ratio of the two areas under the plasma concentration versus time curve for the two drugs. The mean bioavailability of ethinyloestradiol in the patients with an ileostomy was 55.4 +/- 10.9% (+/- S.D.) compared to a control value of 45.0 +/- 6.1% (p greater than or equal to 0.1). The mean bioavailability of levonorgestrel in the ileostomy patients was 85.2 +/- 13.1% compared to 104.6 +/- 22.3% in the controls (p greater than or equal to 0.1). Women who have an ileostomy following lower bowel surgery can rely on their oral contraceptive preparations being absorbed in the normal way.

摘要

研究了5名因溃疡性结肠炎接受手术并带有回肠造口术的年轻女性中乙炔雌二醇和左炔诺孕酮的生物利用度，并与5名对照受试者的情况进行了比较。分别静脉注射和口服了两种药物的单次剂量，并根据两种药物血浆浓度-时间曲线下的两个面积之比计算生物利用度。回肠造口术患者中乙炔雌二醇的平均生物利用度为55.4±10.9%（±标准差），而对照值为45.0±6.1%（p≥0.1）。回肠造口术患者中左炔诺孕酮的平均生物利用度为85.2±13.1%，而对照组为104.6±22.3%（p≥0.1）。下肠道手术后有回肠造口术的女性可以依赖她们的口服避孕药以正常方式被吸收。