[THE CELLULAR COMPOSITION OF THE EPITHELIUM OF THE VILLUS OF THE MUCOUS MEMBRANE OF THE DUODENUM OF RATS IN THE CONDITIONS OF EPICHLOROHYDRIN AND DRUG INFLUENCE].

Purpose of the research is to study the nature of the disorders of the villi of the duodenal mucous membrane (MM) in conditions of long-acting ECH as well as to substantiate experimentally the effectiveness of the use of the extract of Echinacea purpurea (EP) and thiotriazoline for the purpose of these disorders correction. The withdrawal of the rats from the experiment was carried out on the 1st, 7th, 15th, 30th and 60th day after the completion of the administration of ECH, EP extract and thiotriazoline. Histological processing of duodenum fragments was performed according to the standard method. The cell composition of the villus epithelium of duodenal MM was evaluated using a laboratory microscope of the MC 100 (Micros, Austria) and the Microvisible software (version 1.11.10). The determination of the significance of differences was carried out according to the Mann-Whitney U criterion. Differences were considered significant at p<0.05. Prolonged action of ECH led to a decrease in the number of cells in one villus of duodenal MM. This decrease persisted after the end of the administration of this chemical. There was a decrease in the number of columnar epithelial cells, goblet exocrinocytes and argyrophil endocrinocytes. In rats that did not receive ECH, administration of an EP extract was accompanied by a short-term increase in the number of columnar epithelial cells in one villus of duodenal MM. The administration of thiotriazolin to rats that did not receive ECH caused a short-term increase in the number of cells in one villus of duodenal MM and the number of columnar epithelial cells in the one villus of duodenal MM. The use of EP extract on the background of inhalations of ECH reduced the degree of decrease in the number of cells in one villus of duodenal MM and the number of columnar epitheliocytes in one villus of duodenal MM, reduced the degree and duration of reduction in the number of goblet exocrinocytes in one villus of duodenal MM, reduced the duration of reduction in the number of argyrophil endocrinocytes in one villus of duodenal MM. The use of thiotriazolin during the administration of ECH led to a decrease in the degree and duration of a decrease in the number of cells in one villus of duodenal MM and the number of columnar epithelial cells in one villus of duodenal MM, and also prevented the occurrence of a decrease in the number of goblet exocrinocytes and argyrophil endocrinocytes in one villus of duodenal MM.