Gueudry J, Majo F, Delcampe A, Muraine M
Ophthalmology service, hôpital Charles-Nicolle, Rouen University hospital, 1, rue de Germont, 76000 Rouen, France.
COG Ophthalmology Center, Lausanne, Switzerland.
J Fr Ophtalmol. 2019 Mar;42(3):e83-e94. doi: 10.1016/j.jfo.2019.02.001. Epub 2019 Mar 2.
The corneal limbus is a privileged region on the border between two quite different microenvironments, where corneal epithelial stem cells, numerous melanocytes, and antigen-presenting cells are all concentrated within a richly vascularized and innervated stroma. This situation within the ocular surface confers on it the key functions of barrier, epithelial renewal and defense of the cornea. As an immunological crossroads and since the corneoscleral limbus is directly exposed to external insults such as caustic agents, ultraviolet radiation, microbial agents, and allergens, it is the potential site of many tumoral, degenerative or inflammatory pathologies and may progress under certain conditions to limbal stem cell deficiency.
角膜缘是两个截然不同的微环境之间边界上的一个特殊区域，角膜上皮干细胞、大量黑素细胞和抗原呈递细胞都集中在一个血管丰富且有神经支配的基质中。眼表的这种情况赋予了它屏障、上皮更新和角膜防御的关键功能。作为一个免疫交叉路口，并且由于角膜缘直接暴露于外部损伤，如苛性剂、紫外线辐射、微生物制剂和过敏原，它是许多肿瘤、退行性或炎症性疾病的潜在部位，在某些情况下可能进展为角膜缘干细胞缺乏。
