白塞病患者白细胞介素-2活性分析。T细胞产生和对白介素-2作出反应的能力。

Analysis of interleukin-2 activity in patients with Behçet's disease. Ability of T cells to produce and respond to interleukin-2.

作者信息

Sakane T, Suzuki N, Ueda Y, Takada S, Murakawa Y, Hoshino T, Niwa Y, Tsunematsu T

出版信息

Arthritis Rheum. 1986 Mar;29(3):371-8. doi: 10.1002/art.1780290310.

Abstract

We examined interleukin-2 (IL-2) activity in patients with Behçet's disease. T cells from all patients with Behçet's disease were able to produce normal levels of IL-2 in response to phytohemagglutinin; however, responsiveness to IL-2 was impaired in their concanavalin A-activated lymphoblasts. This defect was due to decreased numbers of cells bearing IL-2 receptors in patients with early active disease; in patients with chronic active or with inactive disease, there was a decrease in density of IL-2 receptors on T cells bearing these receptors. Unresponsiveness of T cells to IL-2 may thus contribute to immunologic aberrations in Behçet's disease.

摘要

我们检测了白塞病患者的白细胞介素-2（IL-2）活性。所有白塞病患者的T细胞对植物血凝素刺激均能产生正常水平的IL-2；然而，其伴刀豆球蛋白A激活的淋巴母细胞对IL-2的反应性受损。该缺陷是由于早期活动期疾病患者中携带IL-2受体的细胞数量减少；在慢性活动期或非活动期疾病患者中，携带这些受体的T细胞上IL-2受体的密度降低。因此，T细胞对IL-2无反应性可能导致白塞病的免疫异常。