糖皮质激素受体与抑郁症。
Glucocorticoid receptors and depression.
作者信息
Whalley L J, Borthwick N, Copolov D, Dick H, Christie J E, Fink G
出版信息
Br Med J (Clin Res Ed). 1986 Mar 29;292(6524):859-61. doi: 10.1136/bmj.292.6524.859.
Abstract
The number of glucocorticoid receptor sites in lymphocytes was estimated and plasma cortisol concentrations measured in 17 depressed patients, 12 patients with chronic schizophrenia, and 31 healthy control subjects. The number of receptor sites was significantly lower in the depressed patients than in either the controls or the patients with chronic schizophrenia, but there were no differences between the groups in the dissociation constants of the glucocorticoid receptors or the plasma cortisol concentrations. When two control subjects were studied intensively over 28 hours a slight diurnal variation in the number of glucocorticoid receptors was detected. The lower numbers of glucocorticoid receptors in the lymphocytes of depressed patients may explain why such patients, who often have hypercortisolaemia, do not show the clinical features of excess production of cortisol.
摘要
对17名抑郁症患者、12名慢性精神分裂症患者和31名健康对照者的淋巴细胞中糖皮质激素受体位点数量进行了估计，并测量了血浆皮质醇浓度。抑郁症患者的受体位点数量显著低于对照组或慢性精神分裂症患者，但在糖皮质激素受体的解离常数或血浆皮质醇浓度方面，各组之间没有差异。当对两名对照者进行为期28小时的深入研究时，检测到糖皮质激素受体数量有轻微的昼夜变化。抑郁症患者淋巴细胞中糖皮质激素受体数量较低，这可能解释了为什么这些经常患有高皮质醇血症的患者没有表现出皮质醇分泌过多的临床特征。
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