1 Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
2 Department of Food, Bioprocessing, and Nutrition Sciences, North Carolina State University, Raleigh, North Carolina.
Breastfeed Med. 2019 May;14(4):249-255. doi: 10.1089/bfm.2018.0074. Epub 2019 Mar 6.
The incidence of diabetes is rising, and with it, the number of pregnancies affected by diabetes. U.S. black women have a disproportionately high prevalence of diabetes and lower rates of breastfeeding. The objective of this study was to quantify the relationship between diabetes before pregnancy and breastfeeding duration among black women in the United States. We analyzed women from the Black Women's Health Study ( = 59,000) to assess the relationship between prepregnancy diabetes and time to breastfeeding cessation occurring up to 24 months postdelivery using Kaplan-Meier survival curves, log rank tests, and Cox proportional hazards models. The study population included primiparous women with births between 1995 and 2009 ( = 3,404). Obesity, hypertension before pregnancy, and family history of diabetes were examined for effect modification. Survival curves demonstrated a markedly reduced duration of breastfeeding in women who had been diagnosed with prepregnancy diabetes ( < 0.01). The hazard ratio for breastfeeding cessation for women with prepregnancy diabetes was 1.5 (95% confidence interval 1.1-2.0) compared with women without prepregnancy diabetes after control for age, body mass index (BMI) at age 18, prepregnancy BMI, other metabolic factors, demographics, and health behaviors. Our results suggest that prepregnancy diabetes is a strong predictor of curtailed breastfeeding duration, even after control for BMI. This underscores the need for targeted lactation support for diabetic women.
糖尿病的发病率正在上升,受糖尿病影响的妊娠数量也在增加。美国黑人女性的糖尿病患病率极高,而母乳喂养率却较低。本研究的目的是定量分析美国黑人女性妊娠前糖尿病与母乳喂养持续时间之间的关系。我们分析了来自黑人女性健康研究( = 59000)的女性数据,以评估妊娠前糖尿病与产后 24 个月内母乳喂养停止时间之间的关系,使用 Kaplan-Meier 生存曲线、对数秩检验和 Cox 比例风险模型。研究人群包括 1995 年至 2009 年期间分娩的初产妇( = 3404)。还检查了妊娠前肥胖、高血压和糖尿病家族史对效应修饰的影响。生存曲线表明,患有妊娠前糖尿病的女性母乳喂养持续时间明显缩短( < 0.01)。与没有妊娠前糖尿病的女性相比,患有妊娠前糖尿病的女性母乳喂养停止的风险比为 1.5(95%置信区间 1.1-2.0),控制了年龄、18 岁时的体重指数(BMI)、妊娠前 BMI、其他代谢因素、人口统计学和健康行为因素后。我们的研究结果表明,妊娠前糖尿病是母乳喂养持续时间缩短的一个强有力的预测因素,即使在控制 BMI 后也是如此。这突显了为糖尿病女性提供有针对性的哺乳支持的必要性。