Department of Medical Ultrasound, First Affiliated Hospital, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Guangzhou, China.
Department of Medical Ultrasound, First Affiliated Hospital, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Guangzhou, China.
Ultrasound Med Biol. 2019 May;45(5):1324-1330. doi: 10.1016/j.ultrasmedbio.2019.01.016. Epub 2019 Mar 6.
This study was aimed at exploring the cutoff value of Young's modulus of ablated tissue and the optimal scale at which shear wave elastography (SWE) can delineate the ablation boundary. The livers of 30 rabbits were radiofrequency (RF) ablated, and ultrasonic imaging, including SWE and contrast-enhanced ultrasound (CEUS), was performed. The ablation boundary in the SWE image was located using CEUS, and the SWE parameters of the boundary were measured to calculate the cutoff value of Young's modulus. The cutoff value of the ablated tissue was 48-50 kPa 2 h to 28 d post-ablation. The regions of increased stiffness in SWE images at a scale of 0-50 kPa overlapped well with the non-enhanced regions of CEUS images in 88% of specimens. Therefore, elasticity values differed significantly between ablated and non-ablated tissues, and the cutoff value for Young's modulus differentiated these tissues. SWE delineated the ablation boundary well at the optimal SWE scale with respect to the cutoff value.
本研究旨在探讨消融组织杨氏模量的截断值以及剪切波弹性成像（SWE）能够描绘消融边界的最佳尺度。对 30 只兔子的肝脏进行射频（RF）消融，并进行超声成像，包括 SWE 和超声造影（CEUS）。使用 CEUS 定位 SWE 图像中的消融边界，并测量边界的 SWE 参数以计算杨氏模量的截断值。消融组织的截断值为 48-50 kPa，消融后 2 小时至 28 天。在 0-50 kPa 的 SWE 图像中，硬度增加区域与 88%的标本的 CEUS 图像的非增强区域重叠良好。因此，消融组织和未消融组织之间的弹性值存在显著差异，杨氏模量的截断值可区分这些组织。SWE 在最佳 SWE 尺度上很好地描绘了消融边界，相对于截断值。
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