腭裂伴或不伴唇裂：11-14 周时鼻咽三角视图和上颌间隙的作用。

Cleft Palate with or without Cleft Lip: The Role of Retronasal Triangle View and Maxillary Gap at 11-14 Weeks.

机构信息

Fetal Medicine Unit, Di Venere and Sarcone Hospitals, Bari, Italy,

Fetal Medicine Unit, Di Venere and Sarcone Hospitals, Bari, Italy.

出版信息

Fetal Diagn Ther. 2019;46(6):353-359. doi: 10.1159/000496842. Epub 2019 Mar 8.

DOI:10.1159/000496842

PMID:30852571

Abstract

OBJECTIVE

To evaluate the presence of maxillary gap (MG) and abnormal retronasal triangle (RT) as markers of cleft palate (CP) with and without cleft lip in the first trimester and to assess their association with the type of orofacial cleft (OC).

METHODS

The RT and the mid-sagittal view of the face were evaluated retrospectively by two operators in 26 fetuses with OC and in 80 normal controls to detect abnormal RT and/or MG. The agreement between operators was calculated.

RESULTS

Amongst the 26 fetuses, there were 15 cases of bilateral, 6 cases of unilateral, and 4 cases of median cleft lip and palate, and 1 case of CP alone. The MG was observed in 18 cases by operator 1 and in 17 cases by operator 2; an abnormal RT was detected in 21 cases by operator 1 and in 22 cases by operator 2. Great agreement between operators was obtained. In controls, MG or abnormal RT was suspected in 6 and 2-4% of cases, respectively.

CONCLUSIONS

RT seems to be more sensitive compared to MG; however, the latter showed an additional diagnostic ability when the secondary palate was involved. Both approaches in combination could be useful in detecting OC in the first trimester.

摘要

目的

评估上颌间隙（MG）和异常后鼻三角（RT）作为伴有或不伴有唇裂的腭裂（CP）的标志物的存在，并评估它们与口腔面裂（OC）类型的关系。

方法

由两名操作人员对 26 例 OC 胎儿和 80 例正常对照进行 RT 和面部中矢状面的回顾性评估，以检测异常 RT 和/或 MG。计算了操作人员之间的一致性。

结果

在 26 例胎儿中，有 15 例双侧、6 例单侧、4 例正中唇腭裂和 1 例 CP 单纯。操作人员 1 观察到 18 例 MG，操作人员 2 观察到 17 例 MG；操作人员 1 检测到 21 例异常 RT，操作人员 2 检测到 22 例异常 RT。操作人员之间具有很好的一致性。在对照组中，分别有 6%和 2-4%的病例疑似 MG 或异常 RT。