Lacy P E, Scharp D W
Annu Rev Med. 1986;37:33-40. doi: 10.1146/annurev.me.37.020186.000341.
Remarkable progress made in the past few years has brought pancreatic islet transplantation to the threshold of human clinical trials. Islet transplants have reversed diabetes in experimental animals and prevented or reversed early diabetic complications in the recipients. Methods have been developed that prevent rejection of islets transplanted across major histocompatibility barriers in rodents without requiring the continuous use of immunosuppressive drugs to maintain the transplants. A new method has been developed for isolating 40% of the islets from a single human pancreas. Based upon these accomplishments, the first phase of human clinical trials on islet transplantation was initiated during the past few months.
过去几年取得的显著进展已将胰岛移植推向人类临床试验的门槛。胰岛移植已使实验动物的糖尿病得到逆转，并预防或逆转了受体的早期糖尿病并发症。已开发出在啮齿动物中跨越主要组织相容性屏障移植胰岛时防止排斥反应的方法，且无需持续使用免疫抑制药物来维持移植。已开发出一种从单个人类胰腺中分离出40%胰岛的新方法。基于这些成果，过去几个月启动了胰岛移植的第一阶段人类临床试验。
