Weinstein I, Wilcox H G, Heimberg M
Biochim Biophys Acta. 1986 May 21;876(3):450-9. doi: 10.1016/0005-2760(86)90031-7.
Female and male rats were treated with ethinyl estradiol (5.0 mg/kg daily for 5 days). Control animals were pair fed to compensate for the reduction in food intake induced by the estrogen, or were fed ad libitum. Treatment with ethinyl estradiol reduced total cholesterol and apolipoprotein A-I concentrations in the serum of female and male animals. The concentrations of serum and hepatic triacylglycerol were depressed markedly in animals of both sexes in groups treated with ethinyl estradiol, compared to the control group fed ad libitum. Compared to the pair-fed controls, however, ethinyl estradiol had only a very minor further reduction on serum triacylglycerol concentration. In male and female rats, the synthesis and secretion of triacylglycerol by the liver was, in comparison to the pair-fed controls, stimulated by estrogen, whereas the secretion of unesterified cholesterol was unaffected by any of the treatment regimens. The synthesis and secretion of total cholesteryl esters by livers from male and female rats was increased by treatment with ethinyl estradiol. The hepatic synthesis and secretion of VLDL triacylglycerol and cholesteryl ester was stimulated by ethinyl estradiol in male and female rats, and the VLDL particle was enriched with cholesteryl ester. Treatment with the high-dose estrogen increased the secretion of apolipoprotein A-I by livers from female rats. It is suggested that the depression in the serum concentrations of cholesteryl esters and apolipoprotein A-I is the result of increased rates of hepatic and/or peripheral catabolism of these components and that the hepatic production rates were increased or unaffected in animals administered high doses of ethinyl estradiol. Since the secretion of apolipoprotein A-I by livers from male rats was unaffected by treatment with ethinyl estradiol, the response to estrogen may be sex related.
对雌性和雄性大鼠给予乙炔雌二醇（每天5.0毫克/千克，持续5天）进行处理。对照动物采用配对喂食以补偿雌激素诱导的食物摄入量减少，或者自由进食。乙炔雌二醇处理降低了雌性和雄性动物血清中的总胆固醇和载脂蛋白A-I浓度。与自由进食的对照组相比，乙炔雌二醇处理组的雌雄动物血清和肝脏三酰甘油浓度均显著降低。然而，与配对喂食的对照组相比，乙炔雌二醇对血清三酰甘油浓度的进一步降低作用非常小。与配对喂食的对照组相比，雌激素刺激了雄性和雌性大鼠肝脏三酰甘油的合成和分泌，而未酯化胆固醇的分泌不受任何处理方案的影响。乙炔雌二醇处理增加了雄性和雌性大鼠肝脏总胆固醇酯的合成和分泌。乙炔雌二醇刺激了雄性和雌性大鼠肝脏极低密度脂蛋白（VLDL）三酰甘油和胆固醇酯的合成和分泌，并且VLDL颗粒富含胆固醇酯。高剂量雌激素处理增加了雌性大鼠肝脏载脂蛋白A-I的分泌。提示胆固醇酯和载脂蛋白A-I血清浓度的降低是这些成分肝脏和/或外周分解代谢率增加的结果，并且在给予高剂量乙炔雌二醇的动物中肝脏生成率增加或未受影响。由于乙炔雌二醇处理对雄性大鼠肝脏载脂蛋白A-I的分泌没有影响，对雌激素的反应可能与性别有关。
