Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiania, GO, Brazil.
Department of Cardiovascular Physiotherapy, Faculty of Physical Education - Physiotherapy Course (FAEFI), Federal University of Uberlandia, Uberlandia, MG, Brazil.
Curr Pharm Des. 2019;25(2):109-118. doi: 10.2174/1381612825666190312110836.
Doxorubicin (DOX) is a cytostatic antibiotic from the class of anthracyclines widely used in chemotherapeutic cancer treatments. Despite the efficiency against several types of cancer, the use of DOX remains limited due to the side effects, especially cardiotoxicity. Among the DOX administration strategies, there are the "classic players" such as nanoparticles and polymers, which are capable of DOX delivery directly to interesting neoplastic regions. On the other hand, the "new players" such as phytochemicals and probiotics emerged with the proposal to react with DOX free radicals, reducing the oxidative stress, inflammatory and apoptotic process. Thus, this review aims to report the studies involving these classics and new players along the years that focus on improved administration and reduction of DOX-induced cardiotoxicity.
多柔比星（DOX）是一种广泛应用于化疗癌症治疗的蒽环类细胞抑制剂抗生素。尽管对多种类型的癌症有效，但由于副作用，特别是心脏毒性，DOX 的使用仍然受到限制。在 DOX 的给药策略中，有一些“经典玩家”，如纳米粒子和聚合物，它们能够将 DOX 直接输送到感兴趣的肿瘤区域。另一方面，一些“新玩家”如植物化学物质和益生菌也出现了，它们的作用是与 DOX 自由基反应，从而减少氧化应激、炎症和细胞凋亡过程。因此，本综述旨在报告多年来涉及这些经典和新玩家的研究，重点是改善给药和减少 DOX 诱导的心脏毒性。
