Man'ko V M, Rudneva T B, Filatov A V, Kompaniets N A, Osipova E Iu
Tsitologiia. 1986 Apr;28(4):461-4.
The lymph node cells were treated with monoclonal anti-Lyt-3 antibodies (anti-Lyt-3) and complement. Their interaction with colony-forming units (CFU) of bone marrow was studied. Anti-Lyt-3 did not affect the activity of T-lymphocytes, which changed the pattern of syngenic CFU differentiation in spleen of irradiated mice. On the contrary, the activity of T-lymphocytes, which inactivated proliferation and differentiation of non-syngenic CFU in spleen, was decreased. In the peritoneal cavity of irradiated mice antibodies did not affect the activity of T-lymphocytes which suppressed the colony-formation of non-syngenic stem cells and switched off the activity of T-lymphocytes that stimulated syngenic CFU colony-formation. The subpopulation characteristics of regulatory and effector T-cells has been analysed.
用单克隆抗Lyt-3抗体（抗Lyt-3）和补体处理淋巴结细胞。研究了它们与骨髓集落形成单位（CFU）的相互作用。抗Lyt-3不影响T淋巴细胞的活性，而T淋巴细胞活性改变了受照射小鼠脾脏中同基因CFU的分化模式。相反，使脾脏中非同基因CFU的增殖和分化失活的T淋巴细胞活性降低。在受照射小鼠的腹腔中，抗体不影响抑制非同基因干细胞集落形成的T淋巴细胞活性，也不影响刺激同基因CFU集落形成的T淋巴细胞活性。分析了调节性和效应性T细胞的亚群特征。
Zotero 插件