滑膜肉瘤患者循环肿瘤细胞中SS18-SSX1/2融合转录本的检测。
Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma.
作者信息
Przybyl Joanna, van de Rijn Matt, Rutkowski Piotr
机构信息
Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Poland.
出版信息
Diagn Pathol. 2019 Mar 14;14(1):24. doi: 10.1186/s13000-019-0800-x.
Abstract
A recent study on 15 patients with synovial sarcoma demonstrated very low prevalence of tumor-specific fusion transcripts in peripheral blood specimens. Our results in an independent cohort of 38 patients with synovial sarcoma support these findings. Synovial sarcoma patients could greatly benefit from a non-invasive monitoring of tumor burden by liquid biopsies. However, given the low detection rate of SS18-SSX1/2 in circulation, we conclude that alternative markers other than the tumor-type specific fusion transcripts should be considered.
摘要
最近一项针对15例滑膜肉瘤患者的研究表明，外周血标本中肿瘤特异性融合转录本的患病率非常低。我们在一个由38例滑膜肉瘤患者组成的独立队列中的研究结果支持了这些发现。滑膜肉瘤患者可以从通过液体活检对肿瘤负荷进行的非侵入性监测中大大受益。然而，鉴于循环中SS18-SSX1/2的检测率较低，我们得出结论，应考虑除肿瘤类型特异性融合转录本之外的其他标志物。
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