Gandhi Arun, Vellaiyan Subramani, Subramanian V S, Shanmugam Thirumalaiswamy, Murugesan Kathirvel, Subramanian Kala
Department of Radiation Oncology, Yashoda Hospitals, Hyderabad, Telangana; Research and Development Centre, Bharathiar University, Coimbatore, Tamil Nadu, India.
Research and Development Centre, Bharathiar University, Coimbatore, Tamil Nadu; Department of Radiotherapy, All India Institute of Medical Sciences, New Delhi, India.
J Cancer Res Ther. 2019 Jan-Mar;15(1):223-230. doi: 10.4103/jcrt.JCRT_1181_16.
The aim of this study is to commission and validate the portal dosimetry (PD) system using an indirect method for flattening filter free (FFF) photon beam of the upgraded c-series linear accelerator.
Varian Medical System clinacs with amorphous-silicon portal imager panel (aSi-1000) do not have PD for FFF beams. Recently, our c-series linear accelerator was upgraded to deliver 6MV FFF (6MVFFF) photon beam with the highest dose rate of 1400 monitor unit (MU)/min. The study, therefore, focuses on the commissioning and validation of PD for the 6MVFFF beam.
An indirect method was implemented to predict the portal dose for FFF beam in Eclipse as the treatment planning system does not have direct prediction algorithm for FFF beam (version. 11). Dosimetrical characteristics of aSi-electronic portal imaging device (EPID) were evaluated for 6MVFFF beam and validation of PD for 6MVFFF beam was performed for open fields along with pretreatment quality assurance of intensity-modulated radiation therapy (IMRT), volumetric-modulated arc therapy (VMAT), and stereotactic radiosurgery (SRS) techniques for 30 patients planned with 6MVFFF beam.
ASi-EPID saturates between 100 and 130 cm source to detector distance (SDD) for 6MVFFF beam and resolved at more than 140 cm SDD. The squared correlation coefficient (R) for MU linearity was found to be 1 (R = 1), and instantaneous dose response linearity at different SDD's was found to be 0.999 (R = 0.999) for the 6MVFFF beam. Maximum gamma area index (GAI) for 3% dose difference and 3 mm distance-to-agreement criteria for IMRT, VMAT, and SRS/stereotactic radiotherapy plans was 97.9% ± 0.3%, 96.3% ± 0.5%, and 98.2% ± 0.2%, respectively.
The results reveal that this novel method can be used to commission portal dosimetry for 6MVFFF beam as it is a convenient, faster, and accurate method.
本研究旨在采用间接方法对升级后的c系列直线加速器的无均整器光子束(FFF)进行射野剂量测定(PD)系统的调试与验证。
配备非晶硅射野成像板(aSi-1000)的瓦里安医疗系统直线加速器没有用于FFF束的PD。最近,我们的c系列直线加速器进行了升级,以提供最高剂量率为1400监测单位(MU)/分钟的6MV FFF(6MVFFF)光子束。因此,本研究重点在于6MVFFF束的PD调试与验证。
由于治疗计划系统(版本11)没有用于FFF束的直接预测算法,因此采用间接方法在Eclipse中预测FFF束的射野剂量。对6MVFFF束评估了非晶硅电子射野成像设备(EPID)的剂量学特性,并对30例计划采用6MVFFF束治疗的患者的开放野进行了6MVFFF束的PD验证,同时进行了调强放射治疗(IMRT)、容积调强弧形治疗(VMAT)和立体定向放射外科(SRS)技术的治疗前质量保证。
对于6MVFFF束,非晶硅EPID在源到探测器距离(SDD)为100至130 cm之间会饱和,在超过140 cm SDD时可分辨。发现6MVFFF束的MU线性度的平方相关系数(R)为1(R = 1),不同SDD下的瞬时剂量响应线性度为0.999(R = 0.999)。IMRT、VMAT和SRS/立体定向放射治疗计划在3%剂量差异和3 mm距离一致性标准下的最大伽马面积指数(GAI)分别为97.9%±0.3%、96.3%±0.5%和98.2%±0.2%。
结果表明,这种新方法可用于6MVFFF束的射野剂量测定调试,因为它是一种方便、快速且准确的方法。