Centre for Tumour Biology, Barts Cancer Institute, London, UK.
Department of Gastroenterology and Hepatology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
J Pathol. 2019 Jul;248(3):257-259. doi: 10.1002/path.5265. Epub 2019 Apr 22.
Extensive bile ductular reactions (DRs) accompany many cholestatic liver diseases such as primary biliary cholangitis and primary sclerosing cholangitis (PSC) as well as parenchymal liver cell diseases such as alcoholic liver disease, non-alcoholic steatohepatitis and HCV and HBV infections. DRs originate from bile ducts or hepatocytes after damage and can be identified by expression of markers associated with cholangiocytes, often being associated with disease progression and fibrosis. In a recent issue of The Journal of Pathology, Govaere et al employed high-throughput RNA sequencing to compare the transcriptomic profiles of DR cells from liver diseases of different aetiology; HCV infection affecting hepatocytes and PSC initially affecting biliary epithelial cells. Both DR transcriptomes were markedly different from that of their neighbouring hepatocytes and 330 genes were significantly differently expressed between the DRs of the HCV and PSC liver diseases. Exploring such gene expression profiles could enable therapeutic targeting of DRs, on the one hand to inhibit liver fibrosis and inflammation and conversely to promote hepatocyte and cholangiocyte regeneration. Copyright © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
广泛的胆管反应 (DRs) 伴随着许多胆汁淤积性肝病，如原发性胆汁性胆管炎和原发性硬化性胆管炎 (PSC) 以及实质肝细胞疾病，如酒精性肝病、非酒精性脂肪性肝炎和 HCV 和 HBV 感染。DRs 在损伤后起源于胆管或肝细胞，可以通过与胆管细胞相关的标志物的表达来识别，通常与疾病进展和纤维化有关。在最近一期的《病理学杂志》上，Govaere 等人采用高通量 RNA 测序比较了不同病因肝病中 DR 细胞的转录组谱；HCV 感染影响肝细胞，PSC 最初影响胆管上皮细胞。两种 DR 转录组都与邻近的肝细胞明显不同，HCV 和 PSC 肝病的 DR 之间有 330 个基因的表达显著不同。探索这种基因表达谱可以使 DR 的治疗靶向成为可能，一方面可以抑制肝纤维化和炎症，另一方面可以促进肝细胞和胆管细胞的再生。版权所有 © 2019 英国和爱尔兰病理学会。由 John Wiley & Sons, Ltd. 出版。
