系统性红斑狼疮患者巨细胞病毒病的危险因素：系统评价。
Risk factors for cytomegalovirus disease in systemic lupus erythematosus (SLE): a systematic review.
机构信息
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Department of Internal Medicine, Singapore General Hospital, Academia Building, Level 4, 20 College Road, Singapore, 169856, Singapore.
出版信息
Adv Rheumatol. 2019 Mar 18;59(1):12. doi: 10.1186/s42358-019-0055-y.
BACKGROUND
Cytomegalovirus (CMV) is an opportunistic pathogen causing reactivation and disease in Systemic Lupus Erythematosus (SLE) patients. This study aims to systematically review the literature for risk factors associated with CMV disease in SLE patients, in order to identify those more susceptible to CMV infection during their treatment.
METHODS
A systematic review was conducted on 4 different search engines and via hand search until May 2017. Studies were included after quality assessment via the Standard Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields (HTA KMET).
RESULTS
Two studies on CMV disease were included. Elevated CMV viral load, higher steroid doses, use of immunosuppressants and disease duration were the most commonly associated risk factors for CMV disease.
CONCLUSION
High CMV viral loads, longer SLE disease duration and higher steroid doses were associated with CMV disease. Further studies studying the risk of treatment drugs and role of interventions in the development of CMV infection are needed.
背景
巨细胞病毒（CMV）是一种机会性病原体，可导致系统性红斑狼疮（SLE）患者复发和发病。本研究旨在通过系统综述文献，确定与 SLE 患者 CMV 病相关的危险因素，以便在治疗过程中识别出那些更容易感染 CMV 的患者。
方法
本研究于 2017 年 5 月前在 4 个不同的搜索引擎上和手动检索中进行了系统综述。经过各种领域原始研究论文质量评估标准（HTA KMET）的质量评估后，纳入研究。
结果
纳入了两项关于 CMV 病的研究。CMV 病毒载量升高、更高剂量的类固醇、免疫抑制剂的使用和疾病持续时间是 CMV 病最常见的相关危险因素。
结论
高 CMV 病毒载量、SLE 疾病持续时间较长和较高剂量的类固醇与 CMV 病有关。需要进一步研究治疗药物的风险和干预措施在 CMV 感染发展中的作用。
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