Division of Bioinformatics, Biocenter, Medical University of Innsbruck, Austria.
FEBS J. 2019 Apr;286(7):1284-1286. doi: 10.1111/febs.14809. Epub 2019 Mar 20.
Mutations in KRAS are often associated with resistance to EGFR-targeting antibody therapy. Using comprehensive systems analyses, GNB5 has been identified as a potential target to overcome therapy resistance targeting the EGFR signaling pathways, whereby the AKT signaling pathway (PI3K) rather than the ERK signaling pathway (RAS) might be dominantly affected. Personalized mathematical modeling and simulations of this signaling pathway/network and respective perturbations are of great utility to customize therapy for patients.
KRAS 突变通常与 EGFR 靶向抗体治疗的耐药性有关。通过综合系统分析,已经确定 GNB5 是一种潜在的靶点,可以克服针对 EGFR 信号通路的治疗耐药性,其中 AKT 信号通路(PI3K)而不是 ERK 信号通路(RAS)可能受到主导影响。对该信号通路/网络及其各自扰动进行个性化的数学建模和模拟对于为患者定制治疗非常有用。