State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
Division of Translational and Regenerative Medicine, Department of Medicine, The University of Arizona, Tucson, AZ, United States of America.
PLoS One. 2019 Mar 20;14(3):e0208687. doi: 10.1371/journal.pone.0208687. eCollection 2019.
There is limited evidence linking the impacts of reduced air pollution on hospital admissions. The potential biological mechanisms are still not completely understood. This study examined the effects of mitigated ambient pollution on hospital admissions and inflammatory biomarker levels in chronic obstructive pulmonary disease (COPD) COPD patients. Daily hospital admissions were compared over 51 days associated with the Asian Games period (Nov 1-Dec 21, 2010) with the identical calendar dates of baseline years (2004-2009 and 2011-2013). A three-year cohort study was conducted with 36 COPD patient participants. The daily particulate matter (PM10) decreased from 65.86 μg/m3 during the baseline period to 62.63 μg/m3 during the Asian Games period; the daily NO2 level decreased from 51.33 μg/m3 to 42.63 μg/m3. Between the baseline period and the Asian Games, daily hospital admissions from non-accidental diseases decreased from 116 to 93, respectively; respiratory diseases decreased from 20 to 17, respectively; and cardiovascular diseases decreased from 11 to 9 during the Asian Games period, respectively. No statistically significant reductions were seen in the remaining months of 2010 in Guangzhou, during the the Asian Games period in the control city, and two other control diseases. Furthermore, we identified significant improvement in CRP and fibrinogen by -20.4% and -15.4% from a pre-Asian game period to a during-Asian game period, respectively. For CRP, we found significant increases in NO2 at lag1-3 days after-Asian game period and significant increases in PM10 at lag1-2 days. Similar effects were also seen with fibrinogen. This discovery provides support for efforts to diminish air pollution and improve public health through human air pollutants intervention. Improved air pollution during the 2010 Asian games was correlated with decreases in biomarkers associated with systemic inflammation in COPD patient participants.
目前，将空气污染减少对医院入院人数影响联系起来的证据有限。潜在的生物学机制仍不完全清楚。本研究调查了减轻环境污染物对慢性阻塞性肺疾病（COPD）COPD 患者入院人数和炎症生物标志物水平的影响。在与亚运会期间（2010 年 11 月 1 日至 12 月 21 日）相对应的 51 天内，将每日医院入院人数与基线年份（2004-2009 年和 2011-2013 年）相同的日历日期进行了比较。一项为期三年的队列研究纳入了 36 名 COPD 患者参与者。在基线期，每日颗粒物（PM10）从 65.86μg/m3降至亚运会期间的 62.63μg/m3；每日二氧化氮水平从 51.33μg/m3降至 42.63μg/m3。在基线期和亚运会期间，非意外疾病的每日入院人数分别从 116 人减少到 93 人，呼吸道疾病分别从 20 人减少到 17 人，心血管疾病分别从 11 人减少到 9 人。在广州其余月份 2010 年、亚运会期间的对照城市以及另外两种对照疾病中，没有观察到统计学上的显著减少。此外，我们发现，与赛前相比，赛中 CRP 和纤维蛋白原分别下降了 20.4%和 15.4%。对于 CRP，我们发现，在赛中后 1-3 天，NO2 的滞后时间有显著增加，在赛中后 1-2 天，PM10 的滞后时间有显著增加。纤维蛋白原也出现了类似的效果。这一发现为通过人为干预空气污染物来减少空气污染和改善公众健康的努力提供了支持。2010 年亚运会期间空气质量的改善与 COPD 患者参与者中与全身炎症相关的生物标志物的降低有关。
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