Kanto Gakuin University, Yokohama, Japan.
Innate Immun. 2019 Apr;25(3):203-212. doi: 10.1177/1753425919835298.
Endotoxin research in recent years at the molecular level has required chemically synthesized lipid A without contamination by other bioactive components. Total synthesis of Escherichia coli-type lipid A was achieved in the 1980s by the challenging spirits of the scientists at Osaka University, Japan. They clarified the role of lipid A in the immunological activities of endotoxin in collaboration with Japanese and German researchers, based on the friendships that existed between them. This article introduces the great contributions made by three generations of professors, Tetsuo Shiba, Shoichi Kusumoto, and Koichi Fukase, at the Laboratory of Natural Product Chemistry at Osaka University, to the study over four decades of endotoxin.
近年来，在分子水平上进行的内毒素研究需要化学合成的无其他生物活性成分污染的脂 A。20 世纪 80 年代，日本大阪大学的科学家以不畏挑战的精神完成了大肠杆菌型脂 A 的全合成。他们基于彼此之间的友谊，与日本和德国的研究人员合作，阐明了脂 A 在内毒素免疫活性中的作用。本文介绍了大阪大学天然产物化学实验室三代教授 Tetsuo Shiba、Shoichi Kusumoto 和 Koichi Fukase 在内毒素研究方面的 40 多年的杰出贡献。
