Harada T, Otsuki S
Clin Ther. 1986;8(4):406-14.
The antimanic effect of zotepine was investigated in 16 patients with manic-depressive psychosis or manic schizoaffective psychosis. Zotepine markedly improved manic symptoms in 75% and afforded at least slight improvement in all patients studied. However, in 50%, zotepine caused conversion from mania to depression. The most frequent side effects were dysarthria in 50%, parkinsonian symptoms in 33%, dry mouth in 28%, and sleepiness in 28%. EEG abnormalities were noted in 22% of patients. The antimanic effect of zotepine was enhanced by lithium carbonate; however, concomitant use of zotepine and lithium possibly increased the incidence of EEG abnormalities. The conversion-to-depression effect of zotepine was not inhibited by lithium. Overall, the concomitant use of zotepine and lithium may be important in the treatment of manic psychoses.
对16例躁狂抑郁症或躁狂型精神分裂症患者研究了氯氮平的抗躁狂作用。氯氮平使75%的患者躁狂症状显著改善，且所有研究患者均至少有轻度改善。然而，50%的患者中，氯氮平导致了从躁狂向抑郁的转变。最常见的副作用为构音障碍（50%）、帕金森症状（33%）、口干（28%）和嗜睡（28%）。22%的患者出现脑电图异常。碳酸锂可增强氯氮平的抗躁狂作用；然而，氯氮平和锂盐同时使用可能增加脑电图异常的发生率。锂盐不能抑制氯氮平导致抑郁的作用。总体而言，氯氮平和锂盐同时使用在躁狂性精神病的治疗中可能很重要。
