中国人种中长链非编码 RNA 多态性与心肌梗死患者甘油三酯和总胆固醇水平的相关性研究。
Association of lncRNA polymorphisms with triglyceride and total cholesterol levels among myocardial infarction patients in Chinese population.
机构信息
Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, China; Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, Harbin 150001, China.
Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
出版信息
Gene. 2020 Jan 15;724:143684. doi: 10.1016/j.gene.2019.02.085. Epub 2019 Mar 18.
AIM
The long noncoding RNAs (lncRNAs) have gradually been reported to be an important class of RNAs with pivotal roles in the development and progression of myocardial infarction (MI). In this study, we hypothesized that genetic variant of cyclin-dependent kinase inhibitor 2B antisense RNA (ANRIL) and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) may affect the prognosis of MI patients.
METHODS
The study included 401 Han Chinese MI patients and 409 controls. Four lncRNA tag single nucleotide polymorphisms (SNPs)-ANRIL rs9632884 and rs1537373, MALAT1 rs619586 and rs3200401-were selected. SNP genotyping was performed by an improved multiplex ligation detection reaction assay.
RESULTS
rs9632884 and rs3200401 SNPs were significantly associated with lipid levels in both controls and MI patients (P < 0.003-0.046). Several SNPs interacted with sex and age to modify total cholesterol, low-density lipoprotein cholesterol, and creatinine levels to modify the risk of MI. No association between the lncRNAs SNPs and susceptibility to MI was found (P > 0.05 for all).
CONCLUSIONS
Taken together, this study provides additional evidence that genetic variation of the ANRIL rs9632884 and MALAT1 rs3200401 can mediate lipid levels in MI patients.
目的
长链非编码 RNA（lncRNAs）逐渐被报道为一类具有重要作用的 RNA，在心肌梗死（MI）的发生和发展中起关键作用。在这项研究中，我们假设细胞周期蛋白依赖性激酶抑制剂 2B 反义 RNA（ANRIL）和转移相关肺腺癌转录物 1（MALAT1）的遗传变异可能影响 MI 患者的预后。
方法
本研究纳入了 401 例汉族 MI 患者和 409 例对照。选择了 4 个 lncRNA 标签单核苷酸多态性（SNP）-ANRIL rs9632884 和 rs1537373、MALAT1 rs619586 和 rs3200401。SNP 基因分型采用改良多重连接检测反应检测。
结果
rs9632884 和 rs3200401 SNP 在对照组和 MI 患者中均与血脂水平显著相关（P<0.003-0.046）。一些 SNP 与性别和年龄相互作用，改变总胆固醇、低密度脂蛋白胆固醇和肌酐水平，从而改变 MI 的风险。未发现 lncRNAs SNP 与 MI 易感性之间存在关联（所有 P>0.05）。
结论
综上所述，本研究提供了额外的证据，表明 ANRIL rs9632884 和 MALAT1 rs3200401 的遗传变异可以调节 MI 患者的血脂水平。
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