Zárate A, García I C, Morán C, Fonseca M E
Horm Metab Res. 1986 Jun;18(6):400-1. doi: 10.1055/s-2007-1012326.
It is known that some acromegalic patients exhibited a paradoxical release of growth hormone (GH) after glucose administration. We have attempted to investigate a relationship between the paradoxical GH secretion with the abnormal glucose tolerance test present in some cases of acromegaly. We also studied the inappropriate increase in GH levels following thyrotropin releasing hormone (TRH) injection which is present in some acromegalics. We found that only those patients who had an abnormal glucose tolerance test exhibited simultaneously, the paradoxical release of GH, moreover, the same patients showed GH release following TRH administration. This observation suggests that some acromegalics have an abnormality in their hypothalamic glucose receptor and such abnormality is associated with abnormal GH secretion when TRH is administered. On basis of these findings it is suggested that the hypothalamus may play an important role in the pathogenesis of acromegaly in these cases.
众所周知，一些肢端肥大症患者在给予葡萄糖后出现生长激素（GH）的反常释放。我们试图研究肢端肥大症某些病例中存在的反常GH分泌与异常葡萄糖耐量试验之间的关系。我们还研究了一些肢端肥大症患者注射促甲状腺激素释放激素（TRH）后GH水平的不适当升高。我们发现，只有那些葡萄糖耐量试验异常的患者同时出现GH的反常释放，此外，这些患者在给予TRH后也出现GH释放。这一观察结果表明，一些肢端肥大症患者下丘脑葡萄糖受体存在异常，且这种异常与给予TRH时GH分泌异常有关。基于这些发现，提示下丘脑在这些病例的肢端肥大症发病机制中可能起重要作用。
