Leduc C, Quoix E
Service de pneumologie, CHRU de Strasbourg, Strasbourg, France.
Service de pneumologie, CHRU de Strasbourg, Strasbourg, France.
Rev Mal Respir. 2019 Mar;36(3):415-425. doi: 10.1016/j.rmr.2018.12.003. Epub 2019 Mar 20.
Antigen-specific immunotherapy also known as cancer vaccination offers a novel approach for the treatment of non-small cell lung cancer patients. It relies on specific priming of the immune system in order to provoke or increase adaptive antitumor immune response against the vaccine component. Several molecules have been developed in lung cancer, based on whole-tumor cells, dendritic cells, peptides, recombinant proteins, or viral vectors. The aim of this review is to describe the mechanism of action of these vaccines and the results of the main clinical studies.
抗原特异性免疫疗法也称为癌症疫苗接种,为非小细胞肺癌患者的治疗提供了一种新方法。它依赖于免疫系统的特异性启动,以激发或增强针对疫苗成分的适应性抗肿瘤免疫反应。基于全肿瘤细胞、树突状细胞、肽、重组蛋白或病毒载体,肺癌领域已研发出多种分子。本综述的目的是描述这些疫苗的作用机制以及主要临床研究的结果。