DCBLD 受体家族：在发育、稳态和疾病中的新兴信号作用。
The DCBLD receptor family: emerging signaling roles in development, homeostasis and disease.
机构信息
Department of Biology, University of Vermont, 109 Carrigan Drive, 120A Marsh Life Sciences, Burlington, VT 05405, U.S.A.
出版信息
Biochem J. 2019 Mar 22;476(6):931-950. doi: 10.1042/BCJ20190022.
The iscoidin, U, and CCL omain-containing (DCBLD) receptor family are composed of the type-I transmembrane proteins DCBLD1 and DCBLD2 (also ESDN and CLCP1). These proteins are highly conserved across vertebrates and possess similar domain structure to that of neuropilins, which act as critical co-receptors in developmental processes. Although DCBLD1 remains largely uncharacterized, the functional and mechanistic roles of DCBLD2 are emerging. This review provides a comprehensive discussion of this presumed receptor family, ranging from structural and signaling aspects to their associations with cancer, physiology, and development.
iscoidin、U 和 CCL 结构域包含 (DCBLD) 受体家族由 I 型跨膜蛋白 DCBLD1 和 DCBLD2（也称为 ESDN 和 CLCP1）组成。这些蛋白质在脊椎动物中高度保守，并且具有与神经丛蛋白相似的结构域结构，神经丛蛋白在发育过程中作为关键的共受体发挥作用。尽管 DCBLD1 仍然在很大程度上未被表征，但 DCBLD2 的功能和机制作用正在显现。本综述全面讨论了这个假定的受体家族，从结构和信号方面到它们与癌症、生理学和发育的关联。
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