尿酸可增强活化的人类中性粒细胞对环氧化酶的刺激作用。
Stimulation of cyclooxygenase by activated human neutrophils is enhanced by uric acid.
作者信息
Pincemail J, Deby C, Thirion A, Dethier A, Deby-Dupont G, Goutier R
出版信息
Prostaglandins. 1986 Jul;32(1):101-5. doi: 10.1016/0090-6980(86)90149-8.
Activated human neutrophils supernatant enhances prostanoids production by bull seminal cyclooxygenase (455% of control). Superoxide anion and hydrogen peroxide are not involved in this stimulation, in these experimental conditions. Myeloperoxidase (by its hemic nature) and HPETEs (by their -OOH function) could trigger cyclooxygenase. In the presence of uric acid (10(-3) M), a potent hydroxyl radical scavenger, the cyclooxygenase stimulation by supernatant is increased until 709% of the control.
活化的人中性粒细胞上清液可增强牛精囊环氧化酶的前列腺素生成（为对照的455%）。在这些实验条件下，超氧阴离子和过氧化氢不参与这种刺激作用。髓过氧化物酶（因其含血红素性质）和氢过氧化二十碳四烯酸（因其 -OOH 官能团）可触发环氧化酶。在存在强效羟自由基清除剂尿酸（10⁻³ M）的情况下，上清液对环氧化酶的刺激作用增加至对照的709%。
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