日本血液透析患者透析前后尿酸差值与长期全因和心血管死亡率的关系：宫崎透析队列研究。
Pre- and Postdialysis Uric Acid Difference and Risk of Long-Term All-Cause and Cardiovascular Mortalities in Japanese Hemodialysis Patients; Miyazaki Dialysis Cohort Study.
机构信息
Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan,
Department of Internal Medicine, Miyazaki Prefectural Nobeoka Hospital, Nobeoka, Japan,
出版信息
Blood Purif. 2019;47 Suppl 2:50-55. doi: 10.1159/000496638. Epub 2019 Apr 3.
BACKGROUND/AIMS: Uric acid (UA) levels are affected by changes in dialysis; however, the relationship between the pre- and postdialysis UA difference (UAD) and mortality remains unclear.
METHODS
A total of 1,073 patients receiving maintenance hemodialysis (HD) were enrolled in this cohort study and followed up for 5 years. Patients were divided into quartile categories according to baseline UAD. Cox's regression analyses were used to investigate the relationship between UAD categories and all-cause and cardiovascular (CV) mortalities while adjusting for potential confounders.
RESULTS
A total of 280 patients died of all causes, including 121 CV deaths, during the follow-up. In the analysis for all-cause mortality, hazard ratios were significantly higher in the lowest UAD group (< 4.7 mg/dL) than in the highest UAD group (> 6.2 mg/dL). A correlation was not observed with CV mortality.
CONCLUSION
UAD correlated with all-cause mortality. UAD may be the most appropriate reference for controlling UA in HD patients.
背景/目的：尿酸（UA）水平受透析变化的影响；然而，透析前和透析后 UA 差值（UAD）与死亡率之间的关系尚不清楚。
方法
本队列研究共纳入 1073 名接受维持性血液透析（HD）的患者，并进行了 5 年的随访。根据基线 UAD 将患者分为四分位类别。使用 Cox 回归分析调整潜在混杂因素后，研究 UAD 类别与全因和心血管（CV）死亡率之间的关系。
结果
在随访期间，共有 280 例患者死于各种原因，包括 121 例 CV 死亡。在全因死亡率分析中，最低 UAD 组（<4.7mg/dL）的危险比明显高于最高 UAD 组（>6.2mg/dL）。与 CV 死亡率无相关性。
结论
UAD 与全因死亡率相关。UAD 可能是控制 HD 患者 UA 的最佳参考指标。
Zotero 插件