山椒酰胺和辣椒素类化合物对高脂血症大鼠血浆及肝脏脂质代谢的影响。
Effects of sanshoamides and capsaicinoids on plasma and liver lipid metabolism in hyperlipidemic rats.
作者信息
Chen Zhaojun, Liu Yongxiang, Wang Hui, Chen Zhongai, Liu Jia, Liu Hui
机构信息
The Potato Institute of Guizhou Province, Guizhou Academy of Agricultural Sciences, Guiyang, 550000 Guizhou People's Republic of China.
出版信息
Food Sci Biotechnol. 2018 Nov 15;28(2):519-528. doi: 10.1007/s10068-018-0466-2. eCollection 2019 Apr.
The objective of this study was to determine the effects of sanshoamides and capsaiciniods on plasma and liver lipid levels and the mRNA expression levels of key receptors involved in cholesterol metabolism in hyperlipidemic rats. A total of 56 three-week-old female Sprague-Dawley rats were assigned to 7 treatment groups based on initial body weight (= 8 rats per group). With certain combinations of sanshoamides and capsaicinoids significantly increased food intake, reduced lipid levels in blood and liver, improved histological characteristics of a fatty liver, down regulated mRNA expression levels of cholesterol 7-alpha-hydroxylase (CYP7A1), 3-hydroxyl-3-methylglutary CoA (HMG-CoA) and Farnesoid X Receptor (FXR) in liver and apical sodium-dependent bile acid transporter, Ileal Bile Acid Binding Protein and FXR in the ileum in hyperlipidemic rats. These results indicated that dietary supplementation with sanshoamides and capsaicinoids reduced blood lipid levels and improved cholesterol metabolism in hyperlipidemic rats.
本研究的目的是确定山椒酰胺和辣椒素类物质对高脂血症大鼠血浆和肝脏脂质水平以及胆固醇代谢相关关键受体mRNA表达水平的影响。根据初始体重，将总共56只三周龄雌性Sprague-Dawley大鼠分为7个治疗组（每组 = 8只大鼠）。山椒酰胺和辣椒素类物质的某些组合显著增加了食物摄入量，降低了血液和肝脏中的脂质水平，改善了脂肪肝的组织学特征，下调了高脂血症大鼠肝脏中胆固醇7-α-羟化酶（CYP7A1）、3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）和法尼醇X受体（FXR）以及回肠中顶端钠依赖性胆汁酸转运蛋白、回肠胆汁酸结合蛋白和FXR的mRNA表达水平。这些结果表明，在高脂血症大鼠的饮食中添加山椒酰胺和辣椒素类物质可降低血脂水平并改善胆固醇代谢。
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