五聚素 3 在伴有先兆的急性偏头痛发作中的水平：急诊科的患者管理。

Pentraxin 3 level in acute migraine attack with aura: Patient management in the emergency department.

机构信息

Health Science University, Gazi Yasargil Research and Training Hospital, Emergency Department, Diyarbakır, Turkey.

Health Sciences University, Gazi Yasargil Research and Training Hospital, Biochemistry Department, Diyarbakır, Turkey.

出版信息

Am J Emerg Med. 2020 Jan;38(1):38-42. doi: 10.1016/j.ajem.2019.04.004. Epub 2019 Apr 4.

DOI:10.1016/j.ajem.2019.04.004

PMID:30961918

Abstract

OBJECTIVES

We investigated the state of inflammation, PTX3 level and other routine inflammatory markers (high sensitivity C-reactive protein [hsCRP], and white blood cells [WBC]), in patients who presented to the emergency department (ED) with migraine. We also investigated the relationship between the clinical presentation, PTX3 level, and other routine inflammatory markers in the emergency management of these patients.

METHODS

The study included 44 patients (group 1) who presented to the ED due to a migraine attack with aura and 44 controls (group 2) with similar demographic characteristics.

RESULTS

The WBC count was 8.82 ± 2.10 × 109/L in group 1 and 7.85 ± 2.04 × 109/L in group 2. The mean PTX3 level was 11.57 ± 3.99 ng/mL in patients who presented at the ED with a migraine attack, and 4.59 ± 1.28 ng/mL in controls. The differences values of WBC and PTX3 between the two groups were significant (respectively; P = 0.031, P < 0.001). ROC analyses indicated significant results for PTX3 as a marker for acute migraine attack. It had a sensitivity of 93% and specificity of 84% at a cut-off value of 5.80 ng/mL.

CONCLUSION

This is the first study to investigate plasma levels of PTX3 in patients with acute migraine. PTX3 as a biomarker may be used as an additional examination to the current subjective criteria to support the diagnosis of patients presenting to the ED with an acute migraine attack.

摘要

目的

我们研究了炎症状态、PTX3 水平和其他常规炎症标志物（高敏 C 反应蛋白 [hsCRP] 和白细胞 [WBC]）在因偏头痛就诊于急诊科（ED）的患者中的情况。我们还研究了这些患者在急诊处理中临床特征、PTX3 水平和其他常规炎症标志物之间的关系。

方法

该研究纳入了 44 例（第 1 组）因偏头痛伴先兆而就诊于 ED 的患者和 44 例（第 2 组）具有相似人口统计学特征的对照组。

结果

第 1 组的白细胞计数为 8.82±2.10×109/L，第 2 组为 7.85±2.04×109/L。就诊于 ED 的偏头痛发作患者的平均 PTX3 水平为 11.57±3.99ng/mL，对照组为 4.59±1.28ng/mL。两组间的白细胞和 PTX3 差值均有显著差异（分别为 P=0.031，P<0.001）。ROC 分析表明 PTX3 作为急性偏头痛发作的标志物具有显著结果。其在截断值为 5.80ng/mL 时的灵敏度为 93%，特异性为 84%。