Iglesias Valentin, Paladin Lisanna, Juan-Blanco Teresa, Pallarès Irantzu, Aloy Patrick, Tosatto Silvio C E, Ventura Salvador
Institut de Biotecnologia i de Biomedicina, Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona, Spain.
Department of Biomedical Sciences, University of Padua, Padua, Italy.
Front Physiol. 2019 Mar 27;10:314. doi: 10.3389/fphys.2019.00314. eCollection 2019.
Prion-like behavior has been in the spotlight since it was first associated with the onset of mammalian neurodegenerative diseases. However, a growing body of evidence suggests that this mechanism could be behind the regulation of processes such as transcription and translation in multiple species. Here, we perform a stringent computational survey to identify prion-like proteins in the human proteome. We detected 242 candidate polypeptides and computationally assessed their function, protein-protein interaction networks, tissular expression, and their link to disease. Human prion-like proteins constitute a subset of modular polypeptides broadly expressed across different cell types and tissues, significantly associated with disease, embedded in highly connected interaction networks, and involved in the flow of genetic information in the cell. Our analysis suggests that these proteins might play a relevant role not only in neurological disorders, but also in different types of cancer and viral infections.
自朊病毒样行为首次与哺乳动物神经退行性疾病的发病相关联以来，它一直备受关注。然而，越来越多的证据表明，这种机制可能是多种物种转录和翻译等过程调控的背后原因。在这里，我们进行了一项严格的计算研究，以在人类蛋白质组中识别朊病毒样蛋白。我们检测到242种候选多肽，并通过计算评估了它们的功能、蛋白质-蛋白质相互作用网络、组织表达以及它们与疾病的联系。人类朊病毒样蛋白构成了一组模块化多肽的子集，广泛表达于不同的细胞类型和组织中，与疾病显著相关，嵌入高度连接的相互作用网络中，并参与细胞中的遗传信息流。我们的分析表明，这些蛋白质可能不仅在神经疾病中发挥相关作用，而且在不同类型的癌症和病毒感染中也发挥作用。
