Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
The 2nd affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Mol Genet Genomic Med. 2019 Jun;7(6):e662. doi: 10.1002/mgg3.662. Epub 2019 Apr 11.
Osteoarthritis (OA) is usually recognized to have a genetic factor, and in our study, we performed a case-control study to analyze the association between 14 single nucleotide polymorphisms (SNPs) in OPG and the risk of knee OA in a Chinese Han population.
Fourteen OPG SNPs were assayed using MassARRAY in 393 patients clinically and radiographically diagnosed with knee OA and in 500 controls. Allelic and genotypic frequencies were compared between the groups. Logistic regression adjusting for age and gender was used to estimate risk associations between specific genotypes and knee OA by computing odds ratios (ORs) and 95% confidence intervals (95% CIs).
We found that the minor alleles of six SNPs in OPG were associated with an increased or decreased risk of knee OA in the allelic model analysis. In the genetic model analysis, we found that rs1905786, rs1032128, rs3134058, rs11573828, rs11573849, rs3134056, and rs1564861 were associated with an increased or decreased risk of knee OA before adjusted by sex and age. And after adjustment, three SNPs (rs1485286, rs1905786, and rs1032128) were identified to have a negative effect on knee OA.
Our results verify that genetic variants of OPG contribute to knee OA susceptibility in the population of northern China. These genetic associations may identify individuals at a particularly high risk of developing knee OA.
骨关节炎（OA）通常被认为具有遗传因素，在我们的研究中，我们进行了病例对照研究，以分析中国人中 OPG 的 14 个单核苷酸多态性（SNP）与膝骨关节炎风险之间的关联。
使用 MassARRAY 在 393 名临床和影像学诊断为膝骨关节炎的患者和 500 名对照中检测了 14 个 OPG SNP。比较了两组之间的等位基因和基因型频率。通过计算比值比（OR）和 95％置信区间（95％CI），使用调整年龄和性别的 logistic 回归来估计特定基因型与膝骨关节炎之间的风险关联。
我们发现 OPG 中的六个 SNP 的次要等位基因与膝骨关节炎的风险增加或降低相关。在遗传模型分析中，我们发现 rs1905786、rs1032128、rs3134058、rs11573828、rs11573849、rs3134056 和 rs1564861 与膝骨关节炎的风险增加或降低相关，在调整性别和年龄后。调整后，三个 SNP（rs1485286、rs1905786 和 rs1032128）被认为对膝骨关节炎有负面影响。
我们的结果验证了 OPG 的遗传变异与中国北方人群的膝骨关节炎易感性有关。这些遗传关联可能会确定特别容易发生膝骨关节炎的个体。
