Miranda Machado Pablo Andrés, Baños Álvarez Iván, Gaitán Duarte Hernando Guillermo
ALZAK Foundation, Cartagena, Colombia. Address: Carrera 65 30-55, Edificio Castellana Sky, Apartamento 507, Cartagena, Colombia. Email:
Centro de Rehabilitación Pulmonar, Cartagena, Colombia.
Medwave. 2019 Mar 26;19(2):e7602. doi: 10.5867/medwave.2019.02.7602.
The presence of anemia in chronic obstructive pulmonary disease is not an infrequent event. Exacerbations of this disease have been associated with an increase in mortality in these patients. It is not clear if the presence of anemia is associated with the risk of exacerbations.
To establish the association between anemia and the incidence of outcomes related to exacerbations of chronic obstructive pulmonary disease.
Analytical study of a dynamic or open concurrent prospective cohort of patients diagnosed with chronic obstructive pulmonary disease at two health care institutions in Cartagena, Colombia, between July 2010 and July 2011.
43.9% had anemia at the start of follow-up. The cumulative incidence of exacerbations was 63% in the anemic vs. 55.5% in the non-anemic group. The cumulative incidence of recurrence of exacerbations was 30.4% in the anemic vs. 38.8% in the non-anemic group. The rate of hospitalizations for exacerbations was 30.4% in the anemic vs. 33.3% in the non-anemic group.
No significant association was established between anemia and the incidence of exacerbations of chronic obstructive pulmonary disease, the incidence of recurrence of first exacerbation, the rate of hospitalizations for chronic obstructive pulmonary disease exacerbations and the recurrence time of the first exacerbation of chronic obstructive pulmonary disease.
慢性阻塞性肺疾病患者中贫血现象并不少见。该疾病的急性加重与这些患者死亡率的增加有关。目前尚不清楚贫血是否与急性加重风险相关。
确定贫血与慢性阻塞性肺疾病急性加重相关结局发生率之间的关联。
对2010年7月至2011年7月在哥伦比亚卡塔赫纳的两家医疗机构诊断为慢性阻塞性肺疾病的患者进行动态或开放同期前瞻性队列分析研究。
随访开始时，43.9%的患者存在贫血。贫血组急性加重的累积发生率为63%，非贫血组为55.5%。贫血组急性加重复发的累积发生率为30.4%，非贫血组为38.8%。贫血组因急性加重住院的比例为30.4%，非贫血组为33.3%。
未发现贫血与慢性阻塞性肺疾病急性加重的发生率、首次急性加重复发的发生率、慢性阻塞性肺疾病急性加重的住院率以及慢性阻塞性肺疾病首次急性加重的复发时间之间存在显著关联。
