α-二氟甲基鸟氨酸在接种伯氏疟原虫子孢子的小鼠中诱导保护性免疫。
alpha-Difluoromethylornithine induces protective immunity in mice inoculated with Plasmodium berghei sporozoites.
作者信息
Gillet J, Bone G, Lowa P, Charlier J, Rona A M, Schechter P J
出版信息
Trans R Soc Trop Med Hyg. 1986;80(2):236-9. doi: 10.1016/0035-9203(86)90022-2.
Mice inoculated weekly with Plasmodium berghei sporozoites while under treatment with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, developed protective immunity against subsequent challenge with this parasite. The percentage of mice protected was similar whether DFMO alone (55%) or DFMO + chloroquine (65%) was used. With chloroquine alone, only 12% of mice were protected. This protection was long-lasting (at least six months). The immunity protected against sporozoites but not against erythrocytic form inoculation. It is suggested that this protection is induced by antigens released from exoerythrocytic schizonts whose further development is inhibited by DFMO.
在用鸟氨酸脱羧酶抑制剂α-二氟甲基鸟氨酸（DFMO）治疗期间，每周接种伯氏疟原虫子孢子的小鼠对该寄生虫的后续攻击产生了保护性免疫。单独使用DFMO（55%）或DFMO + 氯喹（65%）时，受到保护的小鼠百分比相似。单独使用氯喹时，只有12%的小鼠受到保护。这种保护作用是持久的（至少六个月）。该免疫可抵御子孢子，但不能抵御红细胞形式的接种。有人认为，这种保护是由红细胞外裂殖体释放的抗原诱导的，而DFMO会抑制这些抗原的进一步发育。
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