Lee Margaret Yee Wah, Wang Mark Qi Wei, Quan Derrick Lian Wen, Pheng Amos Loh Hong, Hamouda Ehab Shaban Mahmoud
Department of Diagnostic and Interventional Imaging, KK Women's and Children's Hospital, Kampong Java, Singapore.
Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Kampong Java, Singapore.
Am J Case Rep. 2019 Apr 13;20:511-516. doi: 10.12659/AJCR.913228.
BACKGROUND Mesenchymal hamartoma of the chest wall is a rare benign lesion that typically presents in early infancy. However, the clinical presentation can be atypical, with imaging features that mimic infection or malignancy. Imaging combined with histopathology is essential in the diagnosis. A case of mesenchymal hamartoma of the chest wall in a 4-month-old infant is presented. CASE REPORT A 4-month-old infant had an incidental finding of a large right-sided chest wall mass. Initial imaging included thoracoabdominal ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI). Histology of an initial open biopsy was inconclusive. The diagnosis of mesenchymal hamartoma was confirmed by histology of the resection specimen, which showed a benign, mixed, chondroid, mesenchymal, and cystic hamartoma with areas of calcification and ossification. CONCLUSIONS This case showed that the diagnosis of mesenchymal hamartoma of the chest wall, which is characterized by heterogeneous components, may require a combined approach for the diagnosis that includes imaging and histology. Increased clinical awareness of mesenchymal hamartoma in infants may help to guide the approach to the correct diagnosis and prevent unnecessarily radical treatment for this benign condition.
胸壁间叶性错构瘤是一种罕见的良性病变，通常在婴儿早期出现。然而，其临床表现可能不典型，影像学特征可类似感染或恶性肿瘤。影像学检查结合组织病理学检查对诊断至关重要。本文报道一例4个月大婴儿的胸壁间叶性错构瘤病例。病例报告：一名4个月大的婴儿偶然发现右侧胸壁有一个巨大肿块。初始影像学检查包括胸腹超声（US）、计算机断层扫描（CT）和磁共振成像（MRI）。初次开放活检的组织学检查结果不明确。切除标本的组织学检查确诊为间叶性错构瘤，显示为良性、混合性、软骨样、间叶性和囊性错构瘤，伴有钙化和骨化区域结论：该病例表明，胸壁间叶性错构瘤具有成分异质性，其诊断可能需要综合影像学和组织学的方法。提高对婴儿间叶性错构瘤的临床认识，可能有助于指导正确诊断，并防止对这种良性疾病进行不必要的根治性治疗。
