纳米抗体 - 药物偶联物的模块化设计，用于靶向递送至含有 MRI 造影剂的铂类抗癌药物。

Modular design of nanobody-drug conjugates for targeted-delivery of platinum anticancer drugs with an MRI contrast agent.

机构信息

CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.

出版信息

Chem Commun (Camb). 2019 Apr 25;55(35):5175-5178. doi: 10.1039/c9cc01391a.

DOI:10.1039/c9cc01391a

PMID:30984937

Abstract

A multifunctional nanobody-drug conjugate (NDC) was constructed in this work for the targeted delivery of a platinum prodrug and an MRI contrast agent. The NDC can be specifically internalized into EGFR positive cancer cells, resulting in higher therapeutic effect and lower side-effects relative to cisplatin. The Gd-binding domain enables the in situ detection of the drug distribution in vivo.

摘要

本工作构建了一种多功能纳米抗体-药物偶联物（NDC），用于靶向递送电介质和 MRI 造影剂。与顺铂相比，NDC 可特异性地被 EGFR 阳性癌细胞内化，从而提高治疗效果，降低副作用。Gd 结合结构域可实现药物在体内分布的原位检测。